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Although hitchhiker mutants exhibited preaxial polydactyly with six digits on both forelimbs and hindlimbs (Fig. 9B, compare with A), Shh mutants are characterized by shortened and narrowed limbs bearing only a single digit (Fig. 9C), as described previously (64).
Studies from other groups have suggested that the polydactylous phenotype of talpid was attributable to constitutive activation of SHH signaling, in which activation of the SHH pathway occurs in the absence of a SHH ligand (Caruccio et al., 1999).
Elijah looked at his father, Plaxico, covered his lips with his index finger and let out a "shh".
The Metro-North press release lends credence to her concern: customers, it says, will be "self-monitoring," though conductors will be authorized to issue something called a "shh card".
We investigated the in vivo efficacy of a Shh antagonist, cyclopamine, in correlation to the secondary effects induced by this treatment on gastrin levels and acid secretion.
Furthermore, in midbrain explants, dopaminergic projections are attracted to a Shh source.
Similar(18)
The activation of the SHH signaling pathway leads to the expression of the transcription factor glioma-associated oncogene 1 (GLI1), a SHH-targeted mediator [ 54].
The hnn mutant cilia are short with a specific defect in the structure of the ciliary axoneme, and the hnn neural tube shows a Shh-independent expansion of the domain of motor neuron progenitors.
MPsShh+ were able to enhance FGF2, FGF5 and VEGF A, B and C mRNA levels, by a Shh-dependent mechanism for FGF5 and VEGF A and by a Shh-independent mechanism for FGF2 and VEGF B and C (Table 1).
In addition, MPsShh+ treatment decreased MT1-MMP and MMP-2 expression levels by a Shh-dependent mechanism.
To prepare a Shh-N-conditioned media, an expression vector that encodes full-length N-terminally-Myc-tagged and C-terminally-S-tagged Shh was transfected into HeLa or HEK293 cells.
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