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A severe defect is reported when a target, presented for the fourth time, at maximum contrast, is not seen.
Mutant age3Δ cells have a severe defect in filament formation under several different hyphal growth conditions.
Worms fed with E. coli expressing Mak proteins showed a severe defect in defecation.
These observations suggest that the acquisition of motor skill may remain relatively unaffected by lesions that give rise to a severe defect of general memory.
On Monday, doctors removed Beatriz's fetus — which had a severe defect that prevented the brain from developing — through an incision in her abdomen.
Limbal stem cell deficiency (LSCD) is a severe defect of the limbal stem cells leading to vision loss due to conjunctival epithelial invasion and neovascularization.
Although the mutant replicated at a similar rate to the parental line (Supplementary Fig. 3b), a severe defect in invasion was observed with an invasion efficiency reduced by 90% compared with the parental line (Fig. 5d).
For example, the knockout mutants of GAMYB in rice showed a severe defect in spikelet development, particularly in anther and pollen development (Kaneko et al. 2004).
The most extreme mutant exhibited a severe defect in progression through the cell cycle; on synthetic medium, the cells progressively accumulated nucleus-containing small buds that generally failed to complete bud enlargement and cytokinesis.
Neutrophils from a five-year-old boy with recurrent bacterial infections failed to spread on surfaces, leading to a severe defect in chemotaxis and a mild impairment in phagocytosis.
Consistent with the roles for these cytokines in Treg differentiation in the thymus, in mice with a T cell-specific deficiency in STAT5 expression a severe defect in Treg development was observed (Burchill et al., 2007).
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CEO of Professional Science Editing for Scientists @ prosciediting.com