Sentence examples for A principal problem from inspiring English sources

A principal problem of insurance risk theory is to find the probability of ultimate ruin.

A principal problem for the law is to keep various kinds of experimentation within bounds.

A principal problem in exploring the lunar ionosphere using the AKR is calculating theoretical phase patterns accurately.

A principal problem with many QTL mapping efforts is the limited size of the mapping population [ 30- 33].

A principal problem, however, is to obtain experimental data for each of these candidates, such as the full-length RNA sequence and its function.

A principal problem in any system of analysis of digital images of PCO is that of artefactual light reflections spoiling the image.

Author's response: While preparing the paper we faced an obvious principal problem as proving a nonexistence of anything is usually difficult and to some extend dubious.

Reconstruction of a gene evolution along a species tree is an interesting and principal problem.

The comic characters Mr. De Niro has been playing in the last few years, like Louis and the smiler-with-a-knife political consultant of "Wag the Dog" (1997), represent, I think, an ingenious solution to his principal problem as an actor: how to use his enormous reserves of power without becoming predictably, formulaically "powerful".

This is the principal problem with a system of support that is based on historical data - it does not reflect current reality.

Therefore, the principal problem for a test specimen-fixture assembly is that it is designed such that the loading history of the recovered specimen is known.