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Although the method is innovative in that it utilizes the actual gene-expression data, it is still limited in that a) it requires a pre-determined objective function for the condition associated with the gene-expression data, and b) the flux limit for each reaction is purely determined by the value of gene-expression values, and hence is unlikely to account for metabolic regulation.
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Earnings management involves the manipulation of company earnings towards a pre-determined target.
The ability of patients to report pain using the three pain scales supports previous observation that pain assessment involves an estimation of pain intensity according to pre-determined objective criteria such as the use of pain scales [ 30].
Furthermore, most conferences lack comprehensive evaluation strategies and as a result, their success based on pre-determined objectives is rarely captured [ 4, 5].
This study evaluates the International Forum on Evidence Informed Health Policymaking (EIHP), a three-day meeting held in Addis Ababa, Ethiopia, in 2012, to determine the success of the meeting based on pre-determined objectives.
Indeed, he expressly dismisses it later (III.30) when, referring to a view of the CSP that executive [Government] Departments needed scientific support, he states flatly that they "do not need scientific support but applied R&D, to achieve specific, pre-determined objectives".
As similar initiatives in the 1990s the program did not meet the pre-determined objectives.
The Assembly Line Balancing Problem ALBPP) consists in assigning tasks to operators engaged on a line in such a way that the final item is produced according to a pre-determined production rate and by optimizing pre-defined objective functions.
Using a pre-determined scale, assessments are based on clearly defined learning objectives and grading rubrics so students know the instructor's expectations for an A, B, C, etc.
"Taking this into account, there were little grounds to expect that the final report of a process that was politically motivated and highly opaque, and prepared with a pre-determined 'correct' result in mind, would suddenly turn out to be objective and balanced," she said.
Sub-population is a new approach for solving multi-objective problems by fixing each sub-population for a pre-determined criterion.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com