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Thus, Walker A mutations in RIG-I are detrimental to signaling only on longer RNA ligands.
(A) Mutations that result in T122K and Arg161Gln plus Cys163Ser amino acid changes in AGU.
(A ) Mutations of CycT1 contact residues reduce AFF4 affinity.
A mutations associated with non-nucleoside RTI (NNRTI), K101E was detected in one case.
(A ) Mutations observed in the citrate synthase protein-coding sequence or upstream intergenic region.
(A ) mutations discovered in CB2000 were moved individually and in combination into the Founder Δe14 background.
Similar(27)
Proviral DNA from A3H-restricted viruses showed high levels of G-to-A mutations in an A3H-specific GA dinucleotide context.
For HIV, G-to-A mutations are more common than other mutations.
Next, we asked if the CDK-A/PAK-A mutations had any effect on the GEF activity of Cdc24.
Therefore, the bias for G-to-A mutations of HIV-1 works in favor for M184I, while the selective pressure for enzymatic efficiency selects for M184V.
The Inr-a mutations have previously been described (Rabinow et al. 1991).
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