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The assumption made was that a moiety of an AT and the corresponding hapten moiety of the proper antigen superimpose each other in terms of conformation.
The six carbon acidic sugar 2-keto-3-deoxymanno-octulosonic acid (Kdo) is a component of the lipid A moiety of the LPS in Gram-negative bacteria.
The HMBC correlations of H-14/C-5, C-6, C-7 and H-7/C-5, C-6 suggested a moiety of C-5 C-6 C-7 with a methyl (C-5 C-6 C-7hed at C-6.
In 1782, Wodrow served as an executor of the last will and testament of his uncle Alexander Wodrow, a wealthy merchant, and sold his personal estate, a moiety of two land lots in Falmouth, and 212 acre along the Rappahannock River in Stafford County to pay his uncle's debts, with the remainder of the proceeds directed to his other family members.
TAP-tagged proteins were detected using the antibody against the protein A moiety of the TAP-tag (PAP; Sigma).
MD-2 is a member of a small class of lipid binding proteins and interacts directly with the lipid A moiety of LPS [9], [10].
Similar(28)
AP is capable of dephosphorylating the lipid-A moiety of endotoxin, converting it to a non-toxic monophosphoryl product [ 2- 7].
These results demonstrate that HPep1 and HPep6 bind to the polysaccharide and lipid A moieties of LPS respectively.
Among them, synthetic peptides HPep1 and HPep6, which are located in the A and B box domains of HMGB1, bind to the polysaccharide and lipid A moieties of LPS respectively.
In this study, we describe two HMGB1 synthetic peptides (of 12 tested) that can bind to LPS, namely HPep1 (HMGB13 15) and HPep6 (HMGB180–96); these peptides bind to the polysaccharide and lipid A moieties of LPS respectively.
Generally, replacement of a moiety by another of similar shape and size does not change the overall packing.
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