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CsA: Cyclosporine A; MMPs: Matrix metalloproteinases.
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Mca-KPLGL-Dpa-AR-NH2 is a fluorogenic peptide substrate that is a highly specific target for many MMPs including: MMP-1 (collagenase 1), MMP-2 (gelatinase A), MMP-7 (matrilysin), and MMP-9 (gelatinase B).
MMP-2 (gelatinase A), MMP-9 (gelatinase B) (Sier et al, 1996), MMP-7 (matrilysin) (Honda et al, 1996) and MMP-14 (MT1-MMP) (Nomura et al, 1995) are over-expressed in human gastric cancer.
The three most commonly studied human metalloproteinases are MMP-2 (gelatinase-A), MMP-3 (stromelysin), and MMP-9 (gelatinase-B).
(ii) Gelatinases include gelatinase-A (MMP-2) and gelatinase-B (MMP-9), mainly digest denatured collagens (gelatins).
The middle band was gelatinase-A (MMP-2), which was about 72 kDa.
VEGF-A, MMP-9 and IP-10 were measured by Flow Cytometry with Flow Cytomix Simplex kits (eBioscience).
The gelatinases (MMP-2/gelatinase A and MMP-9/gelatinase B) are overproduced in joints of patients with RA [ 16- 18].
In a broad sense, an MMP is defined as a pair of molecules that differ by a minor single point change only.
MMP-2 (gelatinase A) and MMP-9 (gelatinase B) constitute the gelatinases.
Any influence exerted on MT1-MMP by cytokines may be of particular interest because of its specific interaction with MMP-2, an MMP with a broad substrate specificity.
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