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Discover Ludwig'A major obstacle' is a correct and usable phrase in written English
It can be used in any context where a difficult or challenging thing stands in the way of achieving a goal. Example sentence: Running a marathon is a major obstacle for many athletes.
Exact(60)
A major obstacle is Mosul.
A major obstacle will be the language barrier.
A major obstacle is the necessity of recombinant enzyme production.
Even stairs are a major obstacle.
But there was a major obstacle: Syria's support for Hezbollah.
The Drava River was certainly a major obstacle.
Laurent Kabila was a major obstacle to peace in Congo.
For Fidyka, though, a major obstacle remained: the cost.
Intratumor heterogeneity is a major obstacle in successfully eradicating tumors.
REGULATORY mandates are a major obstacle to global scientific collaboration.
Articular cartilage repair remains a major obstacle in tissue engineering.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com