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The phrase "a major challenge" is grammatically correct and can be used in written English
It is often used to describe a difficult or significant obstacle or problem. Example: "The company faced a major challenge when their main supplier went bankrupt, causing delays in production and a decrease in revenue."
Exact(60)
A major challenge is emissions leakage.
A major challenge, however, is achieving selectivity.
A major challenge regards the detection and monitoring of delaminations.
A major challenge in this approach is about trust mechanisms.
A major challenge is student understanding of statistics.
A major challenge will be data collection.
A major challenge for aquaculture is containment.
A major challenge, however, is the interpretation of these values.
This is a major challenge".
This poses a major challenge.
Privacy was a major challenge as well.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com