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A main problem is the lack of a discernible end to the spreading protests.
A main problem has been the assumption of thermodynamic equilibrium for what is a metastable system.
A main problem is, however, the lack of experimental data in the literature.
A main problem related to applied ethics is the place of moral principles and moral practices.
A main problem here is what kind of deliberation, justification, or reasoning is supposed to be at work.
A main problem encountered in control engineering is the estimation of unknown parameters appearing in the plant equations.
A main problem related to the n − k analysis lies in the tremendous number of possible contingencies for a bulk power system.
A main problem of clinical phenotyping is that the definition is often biased, as mostly only the most dominant disease feature is used for classification [5].
A main problem addressed in this series concerns the use of previous results on orbital flatness of a model for single substance crystallization.
A main problem is bubble formation in microelectrodes which has an impact on the electrical properties of the electrode and thus it influences the quality of the recording.
A main problem of studies based on self-administrated questionnaires is to correctly diagnose patients with the co-existence of two or more headaches, usually migraine and tension-type headache.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com