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The studies reviewed here used a large number of outcome measures with little justification of their appropriateness or robustness [ 48].
In our comprehensive study, we performed numerous association tests between a large number of outcome measures and 12 different phthalate metabolites.
Our sample size of scanned subjects is comparable with other fMRI studies investigating food reward 10 31 and phenotyping studies after bariatric surgery, 5 but there were a large number of outcome measures that were not corrected for multiple comparisons.
Current research suggests that such overestimation is less prominent in trials accumulating a large number of outcome events [ 16], such as PROWESS (469 outcome events and p = 0.005 for overall survival benefit).
Since currently a large number of outcome trials is ongoing [ 28] of which the majority also collects biomarker samples, we expect a plethora of opportunities for targeted and untargeted biomarker research initiatives in this field within the next years.
A thorough search strategy was employed in this systematic review and it identified a large number of outcome measures and studies, but it is possible that relevant measures were missed.
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"The study results were unequivocally negative across a large number of outcomes that potentially may be influenced by the estrogenic or anti-estrogenic activity of phytoestrogens," researchers wrote in The Journal of the American Medical Association.
"Whenever you measure a large number of outcomes you increase the risk of chance findings," he said.
Follow-up was complete for all deaths and a large number of outcomes (deaths) were recorded.
While a large number of outcomes are potentially relevant, 25 only a limited number was presented in the studies.
Due to the challenge of capturing a large number of outcomes, published studies rarely have a prospective cohort or controlled study design [ 14].
More suggestions(15)
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