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A key difficulty in optimization under uncertainty is in dealing with an uncertainty space that is huge and frequently leads to very large-scale optimization models.
A key difficulty in the spatial discretization process is maintaining a balance between the aggregation-induced information loss and the increase in computational burden caused by the inclusion of additional computational units.
A key difficulty in any assessment of life quality is that it is bound up with individual expectations.
A key difficulty in developing good diagnostic algorithms is the lack of a gold standard for diagnosing malaria.
A key difficulty in assessing the potential overlaps with these clinical constructs is the dearth of studies that utilize standardized questions about the individual's subjective experience of immobility or that directly assess motor and autonomic state.
A key difficulty in addressing this problem is that expansion of biomedical information is asymmetric – different areas of knowledge grow at different rates which in turn vary (and are ascribed differing priorities) during different periods (Fig. 1B).
Similar(49)
A key difficulty resides in studying these mechanisms in vivo, and in untangling factors intrinsic to CF (compared to other diseases with similar neutrophilic inflammation, such as COPD), and those affected by exogenous drugs.
"A key difficulty for home buyers in New Jersey," she said, "has been that a lot of the service people they call don't show up -- or the attitude is 'I'll be out when I can.' "We continually check to make sure the people on our list are reliable and responsive," she added.
A key difficulty is that Mei Xiang places herself in what he called "pancake position" — flat on her stomach, legs outstretched — and Tian Tian isn't assertive enough to lift her off the ground.
The key difficulty in conducting an IV analysis is finding and justifying a strong instrument, especially if the research questions revolve around multiple instruments and predictors.
The key difficulty in designing a program of this type is to preserve its simplicity.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com