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A CTC is then (by definition) a parameterized closed spacetime curve whose tangent is everywhere a future-pointing timelike vector.
A CTC (5-Cyano-2,3-ditolyl tetrazolium chloride) rapid staining kit for microscopy (Dojindo Laboratories, Kumamoto, Japan) was used for cell respiratory detection.
A CTC or BM-DTC cluster was defined as a group of two or more CTCs or BM-DTCs, respectively.
A CTC was identified by strong positive panCTC mRNA staining, positive nuclear staining (DAPI channel), and no CD45 mRNA signal.
A CTC health service provider can be based in the community or in a basic primary care facility.
A CTC is defined as a cell staining for pan-CK and DAPI, but not for CD45.
A CTC count of ≥5 CTCs per 7.5 mL was significantly associated with shortened overall survival (OS) and progression free survival (PFS) [ 1– 4].
A CTC was identified as a nucleated (DAPI-positive) cell with positive staining of CTC markers but no staining for CD45.
A CTC is defined as a nucleated cell staining positively for cytokeratin and negatively for CD45 and results are reported as CTC number per 7.5 ml of blood.
Furthermore, referring to the standard HER2 testing that uses immunohistochemistry (IHC), we proposed a CTC HER2-positive criterion, defined as >30% of CTCs over-expressing HER2.
If the VC was that the image was a CTC, then there had to be >60% agreement on the CTC being either HER2- or HER2+.
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