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The Guardian judges applauded Unilever's achievement, saying: "It's an impressive example of a big impact and a coordinated shift in business practices".
Changes in metabolite (Phe) and related transcripts in Shiraz were greater than CS, indicating a coordinated shift of central metabolism fueling the biosynthesis of specialized compounds in both cultivars, but to a greater extent in Shiraz.
However, B RDEE enables these two strands to move away from each other locally, whereas in the BD conformations, the strands were observed to move together in the same direction, as part of a coordinated shift of the entire active site's backbone.
Taken together, these results do not support E-cadherin loss alone being sufficient to induce a coordinated shift to a mesenchymal phenotype, however they do provide evidence for a direct link between E-cadherin regulation and aspects of tissue remodelling.> -wrap-foot> Genes with significant ≥2.0 fold gene expression changes are presented with inclusion of certain key genes.
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While Moscow and Beijing have generally supported international efforts to end Iran's nuclear weapons program, they clearly were not prepared to go as far as Washington was, and any coordinated shift in their approach could instantly gut America's policy on the issue and endanger its security and energy interests.
"It's a huge, coordinated shift," said Dr. Bohnert.
The transcriptomes of single infected macrophages and phagocytosed C. albicans displayed a tightly coordinated shift in gene expression co-stages and revealed expression bimodality and differential splicing that may drive infection outcome.
However, none of these changes is easily explained as a response to altered environment or stress in the absence of a coordinated transcriptional shift and there is little evidence for major transcriptional remodeling of ER chaperones during development.
By linking their needs to those for national, regional, and global public health, a coordinated technology shift would be possible, and a powerful argument for financing could be developed that would be attractive to development agencies and global foundations, providing evidence regarding current costs and estimations of potential cost savings.
Thus the coordinated shift in HOXA/HOXB loci methylation is strongly associated with a similar shift at the HOXA/B expression levels, with genome wide methylation patterns, as well as with previously described molecular (gene expression) subtypes of UC.
The most salient community (p-value of 1.82e-14) shown is the densely intra-connected community 1, incorporating 40 of the 71 nodes and exemplifying the highly coordinated shift across the year taking place in dehydrated seeds.
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