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A physiological role for AVP in skeletal muscle is suggested by the expression of the AVP receptor (V1aR) in human skeletal muscle [30], [31] and of the oxytocin receptor (also a AVP target) in cultured human myoblasts [32].
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Prior to establishing her company, she was an AVP at Drexel Burnham, a training specialist for Salomon Brothers and a Speech Pathologist for the NYC schools.
Studies have indicated that defective urinary concentration ability may be an impairment of the AVP stimulated water reabsorption in the collecting ducts, either by an AVP resistant down regulation of AQP2 or down regulation of the V2 receptor protein [ 43- 45].
16 Healthy women and 18 women with active AN participated in a combined dexamethasone (DXM /corticotrophin releasing hormone (CRH) challenge test and an AVP challenge test.
During NO-inhibition, the more pronounced reduction in renal water excretion after tolvaptan than after placebo indicates that NO promotes renal water excretion in the principal cells by at least a partly an AVP-dependent mechanism.
The authors' conclusions are fully supported by the results of their experiment and prove that dobutamine is indeed a useful agent to reverse an AVP-associated depression in CI and DO2I in this animal model.
However, we cannot exclude an impact of NO on water excretion through an AVP-dependent mechanism, too.
Possible mechanisms for the increase in bilirubin may be an AVP-mediated reduction in hepatic blood flow [ 98] or a direct impairment in hepato-cellular function.
Patients admitted for community-acquired pneumonia often exhibit an AVP-dependent impairment of water excretion [131].
Patients admitted for community-acquired pneumonia often exhibit an AVP-dependent impairment of water excretion [ 131].
Strategies to prevent an AVP-associated impairment in DO2I therefore seem to be of significant clinical relevance.
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