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The medium was changed every 2 3 days for up to 3 weeks or until beating cardiomyocytes were observed.
The treatment was repeated every 3 weeks or until evidence of disease progression, patient refusal or unacceptable adverse reactions.
After injection, the mice were observed daily for 3 weeks or until the animals became sick, when their brains were removed and used for immunofluorescence assay (IFA) or stored at –70°C for further molecular biology procedures.
Dose escalation was considered when at least three patients had been entered at a given dose, and two patients followed for 3 weeks or until all acute toxicities had resolved.
At each dose level, the first patient was observed for 3 weeks or until recovery from acute toxicity (4 weeks for grade 4 toxicity) before further patients were entered at the same dose level.
As soon as enrolled, the primary caregiver was asked to commit to spending ≥8 hours per day in the NICU between 7 am and 8 pm, including attendance at daily medical rounds and a daily education session Monday to Friday for at least 3 weeks or until discharge.
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Patients were followed for 12 weeks or until healing, whichever occurred first.
Most of the displaced workers are receiving unemployment compensation for 26 weeks, or until they find new jobs.
Subjects will receive GS-9883/F-TAF GS-9883/F-TAF GS-9883/F-TAFr until commercially available.
Following baseline scans, ten rabbits (New Zealand White female) were infected with an aerosolized respiratory pathogen (Mycobacterium tuberculosis, H37Rv strain) in a Madison chamber and imaged every 5 weeks post-infection for 38 weeks or until euthanized for necropsy.
Part A is 2 or 4 week intensive PK to evaluate the GS-9883 after which study participants will receive the GS-9883/F/TAF GS-9883/F/TAFimum of 48 weeks or unthroughmercially available.
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