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Mutations leading to substitutions at amino acid 83 and 87 of the QRDR may be in part responsible for the high level of resistance to fluoroquinolones (MIC norfloxacin = 32 64 µg/ml) among the 3 MDR resistant Salmonella Typhimurium isolates.
3) MDR has improved power to detect gene-gene interaction in small to moderate sample sizes.
For each TB-related indicator, a univariate trend across the 3 MDR TB categories (low, middle, and high) was assessed.
All 3 MDR TB patients who had a history of previous treatment had received their treatment during the 3 years before their current diagnosis.
The other 3 MDR Beijing isolates had different VNTR patterns but shared the same SIT1 spoligotype and the same MLPA lineage type (SA+/V+/CHIN+) (Table 2).
The 3 MDR TB patients that had been previously treated for TB were all directly linked to patient 11 and included in the 13-patient network.
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Previously, it has been reported that lapatinib and erlotinib reverse ABCB1- and ABCG2-mediated MDR [31], [32] and that they significantly reduce ABCC10-mediated MDR [33].
The MDR-TB benefit packages are [Table 1]: 1) MDR-TB pre-treatment evaluation, 2) MDR-TB follow-up evaluation, and 3) MDR-TB hospital stay; an innovative financial protection mechanism to absorb OOP expenses incurred by MDR-TB patients from diagnosis to treatment completion across the public and private sector [13].
PCV13 covered all of the 13 MDR serotypes, while PCV10 covered 10 (77%) of the MDR serotypes.
Another gene responsible for MDR is MRP1 (MDR-related protein 1; ABCC1).
0.186 mg sum of IPBC and propiconazole l−1 MDR, corrected for initial measured concentrations n.a.a
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