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(3) Histamine bound to the histamine 1 receptor and induces squalene synthesis in SZ95 sebocytes.
As shown in Figure 3, histamine treatment is accompanied by increased density of neurons expressing vimentin (indicated by red arrows, Figure 3(b) versus Figure 3(a)) while vimentin expression is generally restricted to vascular endothelial cells in untreated samples.
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EP2, EP4 and histamine H1 receptors might thereby provide effective therapeutic targets for treatment of atherosclerosis.
Histamine significantly reduced tonic contractions of uterine strips induced by indolactam V. H1 histamine receptor antagonist abolished relaxation, whereas H2 histamine receptor antagonist had no effect.
It has been shown that tanycytes respond with a fast increase in [Ca2+]i to ATP, glucose8, 9, histamine, acetylcholine8, and sweeteners10.
Oral theophylline slightly reduced airways symptoms and had no influence on FEV1 and PC20 histamine.
In the budesonide 200 μg bd, group PC20 histamine significantly increased (P<0·005) after 2 months of treatment and remained constant; theophylline was unchanged.
We have found that pyrilamine, an H1 histamine antagonist, significantly decreases nicotine self-administration in rats.
B. Alternative entry window for ligands from PDB with doxepin loaded from 3RZE, Histamine H1 receptor, as example.
The top frequent targets are Muscarinic receptor (ACM1), Adrenoreceptor alpha 1A (ADA1A), Histamine receptors (5HT2A), and dopamine receptors (DRD2).
We have found in the rat model that the H1 histamine antagonist pyrilamine and the serotonin 5HT2C agonist lorcaserin also significantly reduce nicotine self-administration.
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