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However, both groups were balanced for the clinical status prior to transplantation and only 5% of patients were in 1st or 2nd relapse and refractory disease.
Three patients (2 MDS/AML, 1 JMML) were refractory to first-line treatment, 8 patients with de novo AML were in refractory first relapse, and one patient with de novo AML was in 2nd relapse after stem cell transplantation (SCT).
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Of those, around 40 relapse.
In contrast, 7 of 12 patients (58%) relapsed (6 CD19+ relapses, 1 CD19− relapse) post-CAR-T cell infusion in the cohort without Flu.
The experimental group consisted of 30 relapse drug at-risk youth who used the developed program.
As a consequence of these enhancements, an improvement in overall and disease-free survival also was observed in the Cy/Flu cohort, wherein only 2 of 17 (12%) patients relapsed (1 CD19+ relapse, 1 CD19− relapse) post-CAR-T cell infusion.
The controlled group consisted of 30 relapse drug at-risk youth who used the drug addicted treatment.
(6) Relapse status was determined as per the investigator's clinical assessment (based on exacerbation of acute symptomatology, hospitalization, etc).
6) Relapse prevention.
There were 152 relapse and 191 relapse-free samples, for a total of 343.
From 80 relapse cases, 71 (89%) paired primary relapse isolates were available and evaluated.
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