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We have found that in GCs of young adult Ts65Dn mice (P40 60), which replicate cerebellar changes in DS (20% shrinking of cerebellar volume, 14% narrowing of the granular layer, 24% drop in GC density) (Baxter et al., 2000; Roper et al., 2006), the electrical properties of the surviving GCs are not identical to those of GCs in wild-type mice.
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