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Treatment according to randomization starts as soon as possible after allocation, with a maximum of 2 weeks delay.
Treatment was delayed for 1 week for patients with ⩾grade 1 diarrhoea (maximum of 2 weeks delay).
If after 2 weeks delay the threshold was not reached, the following dose adjustments were made: If either the platelet count or the neutrophil levels were below the threshold levels, then the lower dose was to be given.
A total of 263 patients (66%) received six cisplatin administrations: 151 without any delay (38%), 64 with 1 week delay (16%), 39 with 2 weeks delay (10%), seven with 3 weeks delay (2%), and two with 4 weeks delay (0.5%).
Of the 58 patients who received the planned six courses of cisplatin, 39 patients reached a dose intensity of 60 mg m−2 week−10 10 patients with a 1 week delay reached a dose intensity of 52.5 mg m−2 week−1 and 9 with 2 weeks delay a dose intensity of 47 mg m−2 week−1.
From the patients that received four (n=30) or five (n=59) administrations of cisplatin, 55 had no treatment delay (14%), 18 had 1 week delay (4.5%), 10 had 2 weeks delay (2.5%) and six had 3 weeks delay (1.5%); from the patients that received one (n=8), two (n=5) or three (n=35) cisplatin administrations, 46 had no delay (11%) and two had a 1-week treatment delay (0.5%).
Similar(54)
We find that flu activity has a 2 week delay and unemployment has a 4 week delay.
Similar to the United State's CDC the MOH also releases their data with a 1 to 2 week delay.
She developed grade 2 thrombocytopenia requiring a 2 week delay.
Amazon.com still displays the same 4 to 6 weeks delay notice.
TB cultures have an 8 weeks delay and false negative results are frequent when the samples are so reduced as those from intraocular fluids [1].
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