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In addition to what we have referred to in our original manuscript, we further cited and discussed the following key points from Natkanski's paper in our revised manuscript: (1) Internalization of antigen from different types of substrates; (2) time scale of the mechanical force under load; (3) rupture force profiles between B1-8-BCR aNP NP antigen.
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As we examine later times the response to the 2nd AP recovers with ∼ 2 time scales: a fast one (∼2-3 ms) and a slow one 40-500 ms).
Figure 1 Time scale of the experiment.
aSee Williamson's four levels of social analysis: belief systems as pointed out here would be at level L2 (time scale 10 to 102).
[28]A time scale T is an arbitrary nonempty closed subset of the real set ℝ with the topology and ordering inherited from ℝ.
In other words, the (S_{Delta}(V)) delta shape operator is observed to be symmetrical when the (Lambda^{2}=mathbb{R}timesmathbb{R}) time scale is taken.
At smaller perturbation values, we show the method captures the shear diffusion mechanism and the rapid relaxation (on Re1/3 time scale) to an axisymmetric state.
Thus, the surface water temperature in Lake Baikal transduces the LOD anomaly, but principally on the longer 16-yr (n = 192) time scale of variability.
Root-mean-square deviation (RMSD) calculations were performed and monitored to ensure that the simulation was stable during the 10ns time scale.
Particularly, one can observe that at slow time scales the glucose 6-phosphate and the fructose 6-phosphate equally contribute to metabolic pools such that they move in a coordinated fashion starting from the 24nd time scale.
For example, p53-induced protein with a death domain (PIDD) binds to NEMO (interaction 44, time scale 1), and later, PIDD binds to RIP1-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD) (interaction 43, time scale 2) [ 28].
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