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Viabilities of heat-treated cells are indicated as "+" and "-". Figure 2 CTC staining cells heat-treated at 45°C for 0, 5, 10, 15, and 30 min.
Thirty-four patients developed ≥Grade 2 CTC bladder toxicity and three developed ≥Grade 2 CTC late rectal toxicity.
As above, the same analysis was performed for different cut-off values with a 2 CTC cut-off showing the best predictive value.
At least 2 CTC per 7.5 mL were detected in 7 of 20 (35%, 95% CI: 12%, 60%) HCC patients and 0 of 9 eligible NMLD patients (p = 0.04, Wilcoxon-Kruskal-Wallis rank test).
Using the 'offset reciprocal model' for successive deterioration from 0 to 5 CTC, we get hazard ratios of 3.98 (1 vs. 0 CTC), 1.58 (2 vs. 1 CTC), 1.26 (3 vs. 2 CTC), 1.15 (4 vs. 3 CTC) and 1.10 (5 vs. 4 CTC).
In a follow-up study from the United States of America with 1571 patients who experienced acute urinary symptoms during treatment, the risk of having grade 2 (CTC 3.0) late adverse effects after 10 years was found to be significantly increased from 12 to 35% (Zelefsky et al, 2008).
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In the majority of the 247 (20.6%) positive samples (median 1 CTC, range 1 256 CTC) only 1 CTC was detected (n = 148, 12.4%).
Therefore, there were 64 polyps in 52 CTC images in the CTC database.
None of the normal control samples had >2 CTCs, 1% had 2 CTCs, and 7% had 1 CTC.
The majority of patients had between 1 and 2 CTCs and five patients had >5 CTCs.
In blood samples from cancer patients, between 0 and 23 618 CTCs were recovered per 7.5 mL, with 36% of specimens yielding at least 2 CTCs.
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