For the first frame F = 1, perform the algorithm thanks to the arbitrary initialization σ ̂ ( i = 0 ) 2 = Λ M 2 chosen with the sufficient condition Λ>>1.
The observation is corrupted by the additive white Gaussian noise with a variance σ 2 chosen such that the signal to noise ratio SNR(=frac {|boldsymbol {h}|^{2}}{sigma ^{2}}) varies in the range [0,40] in dB.
If we note F the index of the current frame, the proposed method is as follows: For the first frame F = 1, perform the algorithm thanks to the arbitrary initialization σ ̂ ( i = 0 ) 2 = Λ M 2 chosen with the sufficient condition Λ>>1.
To test this hypothesis we created destabilising mutations within either arm of stem 2 (chosen to avoid disruption of the 18S rRNA complementary region) in the context of the p2luc-BM2-204 parental plasmid (which encodes the minimal required region for termination-reinitiation [11]).
Isolates obtained from patients 1 and 2, chosen to investigate the clonality of resistance, were genotyped by pulsed-field gel electrophoresis (PFGE).
Figure 4 is based on 10,000 simulations, with log2 σ e 2 chosen from a uniform(−1,7) distribution, and results were binned by realized phenotypic accuracy in 0.1 increments.
