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The association between MMAS and renal failure is also evident in Figure 3 where MMAS is inversely related to eGFR creatinine - cystatin C below 60 mL/min/1.73 m; additionally, all of our patients with a serum methylmalonic acid level above 1000 micromolar have an eGFR creatinine below 60 mL/min/1.73 m.
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The most cytotoxic compounds toward HL60 leukemia cells were 19, 33, and 34 displaying micromolar IC50 values.
At the physiological nanomolar range, adenosine mainly activates A1AR, A2AAR, and A3AR, whereas A2BAR requires micromolar concentrations [ 18].
1uM is generally used to mean 1 micromolar.
We detect two rate-limiting kinetic processes at low (< 200 micromolar) ATP concentrations.
Entinostat exhibits its highest potency against HDAC 1 (nanomolar range) and is less potent against HDACs 2 and 3 (micromolar range).
However, bitter tastes, whose function is to prevent organisms from eating toxic substances, have lower thresholds; quinine is detectable in a concentration of only 8 micromolar.
Cytotoxicity against CEM human leukemia cells was evaluated with IC50 values in the 5 15 micromolar range.
In mice that received the wild-type bacteria, levels of IPA in the bloodstream were around 80 micromolar; in mice that received the engineered version of the bacteria, IPA was undetectable.
A rise in [Ca2+]i to 1 micromolar readily evoked release.
An increase to >30 micromolar depleted the releasable vesicle pool in <0.5 millisecond.
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