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If time to recovery from any toxicity was more than 1 week, subsequent doses were reduced to 80%.
If a 2-week delay was required, or two separate delays of 1 week, subsequent chemotherapy doses (FU bolus; FU infusion; oxaliplatin, but not LV) were reduced by 20%.
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Four isolates were categorised as highly fit, 3 of which were obtained from plasma collected 36 weeks subsequent to Baseline (Figure 6).
Of the 5 PHAEDRA isolates classified as moderately fit, 3 isolates were obtained from plasma collected 52 weeks subsequent to Baseline, and 2 isolates were obtained from plasma collected at Baseline (Figure 6).
Animals received their second immunisation 8 weeks subsequent to their first.
Hemoglobin data collected subsequent to a phlebotomy, or 4 weeks subsequent to a transfusion or bleeding event, were excluded.
Exclusion criteria: Previously enrolled as a case (repeat malaria infection); age <4 weeks; subsequent PCR negative for Plasmodium spp monoinfection.
In patients with objective tumour regression or stable disease who continued treatment beyond 18 weeks, subsequent tumour response was assessed at the discretion of the investigator.
MR-investigations were performed at baseline (pre-treatment) and follow-up (first MRI after a median of 3 weeks (range, 2 5 weeks); second MRI after a median of an additional 5 weeks (range, 3 9 weeks); subsequent MR-studies were performed every 8 weeks (range, 6 8 weeks).
In addition to a baseline visit, timed to coincide with participants having a CT scan for the purpose of radiotherapy simulation, participants will have follow-up visits at 4, 12, 26, 52 and 78 weeks subsequent to the first radiotherapy treatment fraction.
The baseline (preemployment) and first 2 serum samples (day 1 and week 1) should be tested for the presence of antibodies after 1 week and subsequent samples (in parallel with earlier samples) should be tested as they are taken.
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