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The substitution rate among clade 1 viruses in Thailand was lower.
Screening of the natural HCV NS3 polymorphism Q80K is required prior to simeprevir administration due to the reduced susceptibility of genotype 1 viruses carrying this amino acid variant.
However, the 3-valent mosaic immunogens elicited significantly higher neutralizing responses to Tier 1 viruses than the 2-valent mosaic immunogens.
Phylogenetic analysis among Thai isolates indicated that clade 1 viruses in Thailand consist of three distinct lineages: CUK2-like, PC168-like, and PC170-like viruses.
These results provide proof-of-concept for design of HA stem mimics that elicit bnAbs against influenza A group 1 viruses.
Seven brain-grown genotype 1 viruses were tested in a neuroblastoma N2a infection assay [35].
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An analysis of discordant couples reveals that transmitted HIV-1 viruses are typically the most evolutionarily fit.
The antibodies induced by chimeric VLPs presenting MPER domain are able to partially neutralize HIV-1 viruses from clade B and clade C.
Importantly, we found that the antisera had neutralizing activities against HIV-1 viruses containing HIV-1 HXB2 and JRFL envelope glycoproteins.
The coAdpIXPTM 1 viruses were recognized by anti-Flag, and anti-c-myc antibodies (Fig. 2).
To obtain new clues about ICP0's mechanism of action, we constructed HSV-1 viruses that expressed GFP-tagged ICP0.
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