Sentence examples similar to 1 upr from inspiring English sources

Since NMD attenuation is induced by the PERK-peIF2α UPR branch, we examined whether NMD inhibition activates also this UPR branch.

Among the different mechanisms activated by UPR to induce cell death, there is the activation of JNK through the IRE1-XBP1 UPR branch.

Open image in new window Figure 2 UPR and related diseases.

Hac1pi, together with the Gcn4p transcription factor [11], activates transcription of ∼300 UPR target genes [1], [2].

We next asked which protein(s) are potential targets of the IRE-1 UPR pathway in PVD executing dendrite morphogenesis.

Thus, the ambiguous downstream effects of the AP-1, UPR, and NF-κB pathways illustrate an obvious pitfall in applying a pharmacological inhibition strategy for these signaling cascades, since blocking a particular pathway also diminishes any proapoptotic effects of that pathway.

592 genes were assigned to groups "UPR Independent Up" and 603 "UPR Independent Down".

ER stress is sensed and responded by 3 UPR signal transducers viz.

These results indicate that NMD inhibition indeed leads to activation of the PERK-peIF2α UPR branch.

For this, we downregulated PERK expression and analyzed the effect of DTT treatment on the IRE1-spliced XBP1 UPR branch.

The second topmost 'Molecular and Cellular Function' into which the 36 Upr genes enriched was 'Cell Death and Survival'.