Exact(1)
Tf trafficking of information inside the cell and initiation of several signaling pathways are very well defined in mammalian cells: (1) trafficking and insertion of membrane vesicles, (2) inositol-1,4,5-triphosphate and diacylglycerol signaling pathway, (3) MAPK signaling pathway, and (4) growth factors signaling pathway.
Similar(59)
GLR-1 trafficking and synaptic abundance are regulated by ubiquitination.
Nevertheless, UBC-13, like UEV-1, is required to regulate GLR-1 trafficking.
Several E3 ligases regulate GLR-1 trafficking indirectly by ubiquitinating key regulators of trafficking [56], [57].
However, mutations in known ESCRT complex genes do not appear to affect GLR-1 trafficking at a gross level.
Thus, UEV-1 probably regulates the ubiquitination of other proteins that in turn regulate GLR-1 trafficking.
Thus, it is unlikely that PMK-3 and RPM-1 regulate GLR-1 trafficking by affecting glr-1 mRNA levels.
Instead, our data suggests that UEV-1 is ubiquitinating additional factors that in turn regulate GLR-1 trafficking.
Instead, RPM-1 acts with FSN-1 to regulate GLR-1 trafficking, most likely as an E3 ligase.
Restoration of rpm-1 function in presynaptic neurons does not rescue the GLR-1 trafficking defects of rpm-1 mutants.
UEV-1 is expressed broadly in most tissues, yet regulates GLR-1 trafficking cell autonomously in the command interneurons.
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