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NMA regimens included were: 1) TBI alone: dose = 200cGY, 2) fludarabine + TBI 200cGY or 3) fludarabine + cyclophosphamide.
For a further four questions pertaining to interventions (1 TBI, 3 SCI), only case series, case study or cross-sectional study designs were identified.
RIC regimens included: 1) TBI dose >200cGy and <500cGY single dose or TBI dose <800cGY fractionated +/− other agents, 2) melphalan dose ≤150 mg/m +/− other agents, 3) busulfan dose ≤9 mg/kg +/− other agents.
†SF-36 version 1 (TBI, IHD, Migraine, Parkinson, MS, stroke, musculoskeletal): n = 993 *SF-36 version 2 (bipolar y depression): n = 198 Table 5 presents the MTMM Matrix, where the correlations hypothesized as moderate (in bold) were confirmed.
The regimens were defined as MA, RIC and NMA using previously defined guidelines as follows(19, 20): MA regimens included: 1) TBI dose >500cGy single dose or TBI dose >=800 cGy fractionated, with or without cyclophosphamide, 2) standard dose busulfan and cyclophosphamide, 3) melphalan ≥150mg/m +/− other agents, and 4) busulfan total dose >9 mg/kg +/− other agents.
Together, these results suggest that (1) TBI resulted in acute CIRCI with a peak incidence on day 7 after injury; (2) stress-dose HC did not induce CIRCI in rats without injury; (3) stress-dose HC reduced the incidence of CIRCI after TBI, which may be a key factor for reducing mortality in rats with severe TBI.
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The reported Glasgow Coma Scale ranged from 3 to 8 (severe TBI), 9 to 13 (moderate TBI) and 14 to 15 (mild TBI).
The most common ICD-10 diagnoses were S06.2 (diffuse TBI, n=190), and S06.5 (traumatic subdural haemorrhage, n=86).
Fig. 2 Total TBI interview scores Fig. 3 TBI score for each TBI question across all four interviews.
Participants: Over 3 years, 35 TBI subjects with a mean Glasgow Coma Scale score of 6.5 were consecutively enrolled into the trial while on acute care.
Fifty-one were allocated to the Mild (n = 26) or Severe (n = 25) TBI groups, according to preset determinants of severity; 30 admissions with non-TBI trauma constituted the control group.
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