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Pegloticase, the immunogen in this study, is a recombinant mammalian uricase covalently coupled to 10 ± 1 strands of 10 kDa monomethoxy-PEG per uricase monomer [ 6].
It is formed by the substrate-binding loop (helices α6 and α7 in Figure 1), strands β4, β5, and helix α5 [ 20].
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Only one strand was sequenced for amplicons Me3, CG1, (bottom strands), and Me4, CG2 (top strands).
3 positions on 1 strand (6 features) was better than 1 position on 2 strands (4 features), and 5 positions on 1 strand (10 features) was worse than 3 positions on 2 strands (12 features), as would be expected given extra redundancy (Supplemental table S2).
Similar to the canonical WD40 propeller, strand D of blade 8 (strand 8D) is formed by sequences preceding strand A of blade 1 (strand 1A; Figure 2B).
(1 strand) (1 strand) Cut 3 other strands as long as the other.
What we have now is a plate with n-1 strands, it doesn't matter if one of the strands is longer than the others.
Therefore, at the end we expect E n-1 E n-1loops – the n-1 strands are expected to form E(n-1) loops, and we have a 1-loop from the beginning.
In the first situation you are left with n-1 strands plus one loop, which will be neutral, that is, it will be a loop until the end of the procedure.
Move the outside right strand over 2 strands.
Ronald Reagan's economic program restored 3 strands of conservative thinking.
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