Effectiveness measures for patients with PsA included the modified Psoriatic Arthritis Response Criteria (mPsARC) [ 26]; ≥ 50% improvement in the American College of Rheumatology response criteria (ACR50) [ 27]; TJC (0 to 78 joints), SJC (0 to 76 joints), and changes in TJC and SJC; and the Health Assessment Questionnaire Disability Index (HAQ DI, 0 to 3) [ 28].
Of the 20 proteins biomarkers examined, 14 were statistically significantly correlated with DAS28-CRP, 11 with DAS28, 11 with SJC, nine with TJC and six with VAS-GH (with a false discovery rate <0.05).
Table 2 Amplitudes and amplification factors at CB during the SSC Station SSC amplitude (nT) Amplification at CB KOU 43.4 1.67 SJC 56.4 1.28 JAT 54.6 1.33 CB 72.4 – EUS 49.8 1.45 SLZ 45.9 1.58 ALF 50.4 1.44 CB amplification is the ratio of the amplitude at the CB station to that at the other stations.
At baseline, current peripheral arthritis and/or enthesitis was more prevalent than dactylitis, as evidenced by the proportion of patients with a TJC ≥1, SJC ≥1, total enthesitis count ≥1, and dactylitis count ≥1.
During the first 12 months of follow-up (from T0 to T1), PsA subjects were classified as having achieved MDA when fulfilling 5 or more of the following 7 outcome measures at T1: TJC ≤1; SJC ≤1; PASI ≤1 or body surface area ≤3; VAS for pain ≤15; patient global disease activity VAS score of ≤20; HAQ ≤0.5 and tender entheseal points ≤1 [ 20].
Patients were classified as having achieved minimal disease activity (MDA) only when fulfilling five of the following seven outcome measures at T1: TJC ≤1; SJC ≤1; PASI ≤1 or body surface area ≤3; VAS for pain ≤15; patient global disease activity VAS score of ≤20; HAQ ≤0.5 and tender entheseal points ≤1.
The percentage of patients achieving DAS28 ESR) LDA at week 28 was calculated for DAS28 ESR), SJC or CDAI responders at earlier time points.
They had a significantly worse (p = 0.01) functional capacity, significantly more DMARD failures, a significantly higher disease activity (DAS28, SJC, TJC, pain), and significantly higher propensity scores.
Mean baseline scores on VAS pain (53.6), PtGA (61.6) and HAQ-DI (1.49) as well as MDGA (61.9), SJC (11.4) and TJC (14.7) were all indicative of active disease.
There was no significant association between the kind of alcohol and the disease activity variables in the 2010 postal questionnaire (EuroQol, p = 0.96; HAQ, p = 0.33; TJC, p = 0.65; SJC, p = 0.49; VAS global, p = 0.76; VAS pain, p = 0.71).
23 Eligible patients had tender joint count ≥6 (TJC; assessment of 68 joints) and swollen joint count ≥6 (SJC; assessment of 66 joints) and CRP ≥1.2 times the upper limit of normal (ULN), or ESR >28 mm/h.
