Additionally, the overexpressed cyclin D1 and cdk4 could sequester p21 and p27, therefore reducing the repression of the cyclin E/cdk2 activity by these kinase inhibitors.
On the basis of the detection of Hsp90 in the proteomic analysis (Supplementary Table S2), P36 might sequester Hsp90 thus favoring ALK degradation and apoptosis.
Kelch-like ECH-associated protein 1 sequesters Nrf2 through binding to the N-terminal regulatory domain of Nrf2 in the cytoplasm (5).
The Mad2 and the MCC (Mad2-Mad3-Bub3) sequester the Cdc20 and Bub3Mad3 and the MCC degrade it.
Conversely, antiapoptotic Bcl-2, Bcl-xL, and Mcl-1 sequester activator BH3s into inert complexes, which prevents Bax/Bak activation.
The anti-apoptotic proteins (i.e., Bcl-2, Bcl-xl, Bcl-w and Mcl-1) sequester the pro-apoptotic proteins (i.e., Bax, Bok and Bak) that otherwise, upon activation, permeabilize the outer mitochondrial membrane, enabling the release of cytochrome c, promoting the activation of caspases and thereby apoptosis.
Furthermore, MMP-9 and to a lesser extend MMP-2 sequester VEGF, required for the initiation of tumor angiogenesis 41.
Yang H et al. proposed that aggregtes of polyQ-expanded Atx3 sequester VCP into protein inclusions, and leads to neurodegeneration.
We demonstrate that DCs treated with a brief pulse of FK506 sequester and then release sufficient drug to inhibit T cells for an extended period of days.
This enabled RK10 to sequester Cu2+ from Aβ40-Cu2+ species and to arrest the production of reactive oxygen species (ROS) catalyzed by Cu2+ or Aβ40-Cu2+ species.
In areas where actin is mainly polymerized, free Yih1 may sequester Gcn1, thus preventing Gcn2 activation.
