Sentence examples for 1 promiscuous from inspiring English sources

To further assess the ability of several Plasmodium T cell epitopes to enhance vaccine potency, we designed a synthetic gene encoding four Plasmodium yoelii merozoite surface protein 1 (promiscuous+ promiscuous T cell epitopes fused in tandem to the homologous carboxyl terminal PyMSP119 fragment.

HSP40s can be classified into four categories defined by their binding to substrates: (1) promiscuous client binding, (2) selective client binding, (3) no client binding, and (4) unknown client binding.

In short, under initial conditions representing early pancreas development, the key features of gene expression and patterning in the developing pancreas are reproduced by the model: (1) promiscuous expression of the lineage-associated factors Ngn3 and Ptf1a, (2) the transient expression of the pro-endocrine factor Ngn3 and (3) the scattered spatial patterning of committed islet cells.

Interactions supported by prey clones that interacted with more than 18 different baits, i.e. 1% of all interacting proteins, were considered promiscuous interactions and classified in category D. Most promiscuously interacting proteins were soluble proteins, and 10 out of 18 promiscuous proteins possessed at least one protein domain known to cause promiscuous interactions (Supplementary Table 3).

The 30 highest responders at C cpd) = 10 μM, of which 25 were selected in at least one of three screens at C cpd) = 0.5 μM, contained 22 promiscuous binders and 8 potential PTP1B-specific binders with KD ∼ 10−5 M.

Table 4 Promiscuous binders Library Promiscuous binders Elite libraries 1.7 Platinum collection 0.9 DIVERSet™-CL 2.7 DIVERSet™-EXP 2.5 Drug-like set 2.9 Pharmacological diversity set 1.8 Maybridge screening collection 4.6 Prestwick Chemical Library ® 11.8 MSIIfull library 5.0.

These 7 promiscuous epitopes from NP, RdRp and GP were found to have world-wide population coverage of more than 95% indicating their potential significance as useful candidates for vaccine design.

For comparison between Pfam22, Pfam24 and the two HMMER releases (HMMER2.3.2 and HMMER3b3), we removed the top 20, promiscuous conserved domains, as well as Zinc Finger domains for the analysis, as HMMerThread has difficulties of identifying the correct family of Zinc Fingers.

Group 3 (at high risk of sexually transmitted infection) included 85 sex workers and 15 promiscuous men (mean age 25 years, age range 18 43 years).

Only 11 promiscuous T cell epitopes were found in H7N9-HA, and only four of these are somewhat cross-conserved in other strains.

Indeed, of all 145 promiscuous drugs in our dataset, more than 65% have been found to display activities against some proteins from the similar family (sequence similarity ≥ 30%).