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Usually patients with NEB mutation have type 1 predominance, but we have encountered two patients with type 2 predominance.
Another common histologic finding of NM is type 1 predominance or type 1 uniformity [ 21, 22].
Surprisingly, all G1 patients failed to show type 1 predominance and constantly showed absence of 2B fibers.
In fact, type 1 predominance has been reported in some of the patients included in our microarray [ 11, 12].
Type 1 predominance or type uniformity has been reported as a very common feature associated with NM, and many other structural congenital myopathies [ 39].
This finding suggests that G1 NEB-mutated patients were not able to switch towards type 1 predominance due to a possible alteration of muscle maturation.
Similar(45)
In contract to the previous finding of CRF01_AE predominance in 2002-2006, subtype C predominated in both injecting drug users (IDUs) and heterosexually transmitted populations in this study.
However, those combining CD28 transmembrane and co-stimulatory domains showed CD4 predominance and inferior cytotoxicity.
The fetal immune system is characterized by a Th2 bias but it is unclear how the Th2 predominance is established.
Western blot analysis confirmed that the relative ratio of DCC to UNC5H (DCC:UNC5H) expression in the VTA shifts significantly toward UNC5H predominance around puberty.
As one possibility, the increase in nocturnal sleep-associated predominance of type I cytokines might result in the augmentation of total IgG and the Th1 predominance in idiopathic hypersomnia patients.
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