Sentence examples for 1 potency from inspiring English sources

Additional file 1: Potency, selectivity and pharmacokinetics of tofacitinib/CP-690,550 (Janus kinase inhibitor (JAKi )) and PRT-062607 (spleen tyrosine kinase inhibitor (SYKi )).

Many β-lactams preferred GlpG over AarA (Table 1): potency was 67- to 302-fold greater on GlpG than on AarA for L2, L10, L11, L19, L42, and L58.

Interestingly, the 2-chloropyrimidine-4-carboxamide, 31, retained potency at mGlu4, but lost activity at mGlu7/8 compared to the picolinamide.

The E67-2 analogue (72, Fig. 8) retained potency against KDM7A with > 30-fold selectivity over G9a-like methyltransferases.

C1C5 RANTES is a chemokine mutant that exhibits high anti-HIV-1 potency coupled with CCR5 antagonism.

V.12 and IX.1 potency is said to be the principle of motion or change either as the activator or as the receptor of a relevant influence.

Some other compounds, 7k, 7c, 7j and 7e, were also endowed with a favorable anti-HIV-1 potency (EC50 = 0.034, 0.11, 0.11 and 0.16 μM, respectively).

This work culminated in compounds such as 31, which possess good BACE-1 potency, excellent permeability and a low P-gp efflux ratio.

Anti-HIV-1 and cytotoxicity studies of best five RT inhibitor (7a, 7d, 7k, 7L and 7m) revealed that, except compound 7d other compounds retained significant anti-HIV-1 potency with good safety index.

Unexpectedly, compound 8c was found to show moderate anti-HIV-2 potency (EC50 = 5.57 μM).

The data from PubChem is excluded because it often does not include EC50 potency data.