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Progressive osseous heteroplasia (POH) is an ultrarare genetic condition of progressive extraskeletal bone formation (Online Mendelian Inheritance in Man 166350). 1 POH is clinically suspected by cutaneous ossification, usually presenting in early life, that involves subcutaneous and then subsequently deep connective tissues, including muscle and fascia.
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Figure 10 POH and FDR against T 2. Radius refers to minimum radius.
Two of these AAA issues, insured by Ambac, are Indiana Michigan Power (24, IJD) and Public Service of Oklahoma (24, POH), 6% trust preferreds due in 2032.
Mutations in 25 POH kindreds were identical to those observed in PHP1a/PPHP.
Our recent studies found a synergistic anti-cancer effect by combining LY30 and TRAIL (Poh and Pervaiz, 2005; Poh et al., 2007; Shenoy et al., 2009).
The TRAIL effects were adapted from a previously published model (Albeck et al., 2008b), and the LY30 effects were approximated from our previously published experiments on LY30 (Poh and Pervaiz, 2005; Poh et al., 2007; Shenoy et al., 2009).
We next studied ROS effects in greater detail because ROS are known to be produced by LY30 (Poh and Pervaiz, 2005; Poh et al., 2007; Shenoy et al., 2009) as demonstrated by fluorescent measurements of dichlorofluorescin diacetate (DCFDA).
6 POH occasionally presents as an overlap syndrome with additional features associated with other GNAS-based disorders of HO.
Frameshift and other highly disruptive mutations were more frequent in the reported 37 POH kindreds than in PHP1a/PPHP kindreds (97.3% vs. 68.7%, P < 0.0001).
FRI sampling theory has also had impact in various applications (Baboulaz and Dragotti 2009; Poh and Marziliano 2010; Tur et al. 2011; Kandaswamy et al. 2013) and here we focus on an application in neuroscience.
86 POH is diagnosed on the basis of three major criteria: superficial HO that progresses to deep connective tissue; two or fewer AHO features, excluding HO; and no PTH resistance (Table 3).
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