These genes are central to ion homeostasis (PTK2 (YJR059W)), SSQ1 (YLR369W)), NAD recycling (NPT1 (YOR209C)), signalling (PLC1 (YPL268W)), trehalose synthesis (TPS1 (YBR126C), TPS2 (YDR074W)), transcription (SIN3 (YOL004W), ZAP1 (YGR285C)), and ubiquitin recycling (DOA4 (YDOA49C)).
Among the associations we examined, CBAP deficiency led to reduced LAT-ZAP70, LAT-PLC γ1, and PLC γ1-ZAP70 association, but did not affect LAT-GRB2 association.
The Dlc1 protein shows homology with the rat p122RhoGAP protein, which was initially found as a binding partner of Phospholipase C-delta 1 (PLC-δ1), stimulating its activity [ 12].
Using co-immunoprecipitation in Jurkat T cells, we detected ZAP70, LAT, and GRB2, but not SLP76 or PLC γ1, in CBAP-containing complexes (data not shown).
ILNY, it's a gr8 plc," wrote one British student, in an essay composed entirely of texting gibberish (translation: My summer holidays were a complete waste of time.
Compared with LC-CD133−, LC-CD133+ derived from NSCLC Patients No.1 (PLC) and No. 2 (LLC) showed higher invasion activity through Matrigel Transwell invasion assay (p<0.001; Fig. 2C).
EGF stimulates both cell proliferation and motility [ 122], with the later being dependent on EGFR autophosphorylation and the subsequent activation of phospholipase C γ-1 (PLC- γ1).
We found HMQ18 22 could decrease phosphorylation of VEGFR2 Tyr), VEGFR1 Tyr), Akt(Tyr), protein kinase C α (PKC α) (Tyr) and phospholipase-C γ-1 (PLC γ-1) (Tyr).
Suppressor of cytokine signaling 7 (SOCS7) is a member of the SOCS family and is known to interact with phospholipase C γ-1 (PLC γ-1), a key downstream mediator of the hepatocyte growth factor (HGF /C-MET axis.
Further reports showed that HGF/C-MET downstream intermediate phospholipase C γ-1 (PLC γ-1) overexpression was also observed in breast cancer [ 9], and specific PLC γ-1 inhibition was found to block breast cancer invasiveness [ 10].
