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7. Painless vasectomy One of the most controversial picks of the draft.
Eighteen subjects with type 1 diabetes (no DN = 6, painful DN = 5, painless DN = 7) and six healthy volunteers (HV) were recruited.
The presenting complaints were asymptomatic nonvisible haematuria (n=8), symptomatic nonvisible haematuria (n=11), painless visible haematuria (n=6), painful visible haematuria (n=1) and haematospermia (n=2).
There was no difference in the presence of microvascular complications (diabetic retinopathy data from retinal screening database; painful DN [ n = 3], painless DN [ n = 2], no DN [ n = 2], and diabetic nephropathy based on albumin creatinine ratio; painful DN [ n = 3], painless DN [ n = 3], no DN [ n = 1]) between subjects.
No further mutations in CLTCL1 were found in a cohort of 39 painless patients of unknown genetic cause PCRs were designed to cover the region of CLTCL1 containing the c.988G>A mutation, which was within exon 7.
Subjects were divided into the following groups: 1) no DN (asymptomatic subjects with normal NCS, 2) painless DN (pain-free subjects with both clinical and at least two abnormalities of neurophysiologic assessment), and 3) painful DN (painful symptoms together with clinical and neurophysiological abnormalities).
Overall group comparison showed that subjects with painful DN (rCBV 228.7 [19.5]) have the tallest peak concentration of Gd-DTPA and significantly greater mean thalamic rCBV compared with HV (181.9 [51.7]), no DN (202.3 [25.8]), and painless DN (216.5 [65.5]); P = 0.04, χ = 8.3).
The bolus arrival time (in seconds) was delayed in both neuropathy subgroups (painful DN 28.6 [1.6] and painless DN 27.3 [2.4]) compared with HV 23.6 (6.3) and no DN 24.2 (5.9), P = 0.7, χ = 1.3.
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