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One patient treated with ointment 1 reported an application-site AE (erythema); 13 patients (four in the ointment 1 group and three each in the vehicle 1, ointment 2 and vehicle 2 groups) reported predosing burning/stinging at baseline.
One commercially-available purse kit winnows down the contents to 1 ointment packet, 3 cleansing wipes, 2 gauze pads, and 10 bandages.[10] Adding small amounts of your most commonly-used medications to a small zip-close bag would make for a solid first aid kit that should fit nicely in a purse, diaper bag, backpack, etc. Set up special kits as needed.
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Patients were enrolled by the investigators and randomized 2 : 1 : 2 : 1 at baseline using an automated web/telephone randomization system to one of the following treatments: 2% (20 mg g−1) tofacitinib ointment 1; vehicle 1; 2% (20 mg g−1) tofacitinib ointment 2; or vehicle 2. Randomization occurred across all four treatment groups contemporaneously at all investigator centres.
PK data were available from 43 patients treated with tofacitinib (20 with ointment 1 and 23 with ointment 2).
Seventy-one patients were randomized 2 : 1 : 2 : 1 to 2% tofacitinib ointment 1, vehicle 1, 2% tofacitinib ointment 2 and vehicle 2, each administered twice daily for 4 weeks to a single fixed 300 cm treatment area containing a target plaque with or without one or more nontarget plaques and normal skin.
They received calcitriol 3 μg g−1 ointment twice a day for up to 52 weeks.
This paper reviews 15 studies with calcitriol 3 μg g−1 ointment (Silkis®/Vectical™ ointment; Galderma Laboratories) applied twice daily for up to 52 weeks.
27 The efficacy of calcitriol 3 μg g−1 ointment in combination with ultraviolet (UV) B phototherapy was compared with phototherapy alone in an eight-week study.
23 In three separate studies, calcitriol 3 μg g−1 ointment was used to treat moderate or severe lesions of chronic plaque psoriasis localized in sensitive skin areas.
In another two-phase parallel-group study including 125 patients with chronic plaque type psoriasis either calcitriol 3 μg g−1 ointment or calcipotriol 50 μg g−1 ointment were administered in the morning and the topical corticosteroid clobetasol in the evening for two weeks, followed by monotherapy with either calcitriol or calcipotriol twice daily for another 10 weeks.
24 In another intra-individual, randomized, investigator-blinded left-right comparison study including 75 patients with symmetrical mild-to-moderate plaque psoriasis affecting sensitive areas (face, hairline, retroauricular and flexural areas) calcitriol 3 μg g−1 ointment was compared to calcipotriol 50 μg g−1 ointment both administered twice daily.
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CEO of Professional Science Editing for Scientists @ prosciediting.com