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This affected 1 NRPS gene and 7 PKS genes.
One example of an identified cluster was located on contig Node_309 which consists of 5 genes, including 2 PKSs, 1 NRPS putatively coding for enterobactin, a phosphate transferase gene, and a MFS transporter.
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Neuropilin 1 (NRP-1) is a VEGF-A isoform-specific co-receptor (Zachary et al., 2009).
We automatically extracted chemical structures from PubChem [31] for a set of 327 NRPs.
Based on SMURF [ 55], the O. polyrhachis-furcata genome encodes 4 putative NRPS, other 4 NRPS-like, 14 PKS, 1 PKS-like, 1 NRPS-PKS hybrid and without dimethylallyl tryptophan synthase (DMAT) genes (Table 2).
Moreover, 786-O cells express VEGF and neuropilin-1 (NRP-1) rather than VEGFR-2.
The performance of water retention could be increased in NRP-1, NRP-4, and C-1 by +1, +5, and +8 points, respectively.
Angiogenesis strongly depends on the activation of integrins, especially integrin αvβ3, and of neuropilin-1 (NRP-1), a co-receptor of VEGFR2.
Neuropilin-1 (NRP-1) is a co-receptor of VEGFR165 and molecules interfering with VEGF165 binding to NRP-1 seem to be promising candidates as new angiogenesis modulators.
We examined the potential roles and mechanisms of VEGF/neuropilin-1 (NRP-1) axis in regulating the tumorigenesis and metastasis of breast cancer and found the expression of VEGF and NRP-1 correlated with aggressiveness of breast cancer.
Neuropilin-1 (NRP-1) is a co-receptor of VEGFR (vascular endothelial growth factor receptor), but it is also suggested that NRP-1 in tumour cells may serve as a separate receptor for VEGF165.
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