Encouragingly several reports indicate that USE or combined US/USE can attain high NPVs for malignancy in this group (95 100 % NPV) [56, 59, 65, 66], although one study has documented the opposite findings (50% NPV) [39].
Of them, 256 proxies were approached (NVVE n=232, NPV n=24), as 7 proxies could not be reached (NVVE n=6, NPV n=1).
Out of 152 samples, 150 were confirmed true BV-negative with 2 false positive samples (specificity=98.7%), PPV: 91.3%, NPV: 100%.
The diagnostic performances of physical examination and FNAC were: Sensitivity 52/100 %, specificity 88/100 %, PPV 85/100 %, NPV 60/100 %, respectively.
Open image in new window Fig. 12 NPV for different waterflood scenarios.
No significant differences were observed (sensitivity, p = 0.157; specificity, p = 0.157; NPV, p = 0.480; PPV, p = 1).
For composite UWF images, sensitivity was 0.27, specificity was 0.88, PPV was 0.31, NPV was 0.86, positive LR was 2.25, and negative LR was 0.83.
For the conventional Zeiss images, sensitivity was 0.5, specificity was 0.84, PPV was 0.33, NPV was 0.91, positive LR was 3.13, and negative LR was 0.6.
The individual mRNA signatures were validated in an independent dataset of breast tumors (P = 0.002, NPV = 82%).
