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Infarct volume was correlated with length of hospitalization and 6-month outcome assessed with Glasgow Outcome Scale (GOS), Modified Rankin Score (mRS), Barthel Index (BI) and a dichotomized outcome status with favorable outcome defined as GOS 1, mRS or=95.
As summarised in Table 1, MRS shows many metabolic effects caused by different molecular-targeted agents, some of which could be developed as biomarkers of response in early stage clinical evaluation.
A multidimensional Markov structure with four disability categories was adopted, based on the modified Rankin scale (mRS) [ 17]: category 1 (mRS 0-1); 2 (mRS 2-3); 3 (mRS 4) and 4 (mRS 5).
We selected the articles according to the following criteria: (1) MRS studies that involved humans; (2) studies that compared spectra of PD patients to those of healthy controls; and (3) single and multivoxel MRS studies.
1 Mrs A. M. Walden (High Wycombe): Cricketer on tour, possibly Root, unwound with treble G &T (anag.; ref. Joe R .. 2 J. Grimes (Norfolk): Role of Jason going after golden prize in film?
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As an example of PET quality, reconstructed transverse images from scan numbers 1 (13C-MRSI "ON") and 2 (13C-MRSI "OFF") are shown in Fig. 3.
Antagonism of the effects of ATP at P2X2 receptor superimposed on the potentiation was also observed at >10 μM (MRS 2154) or 0.3 1 μM (MRS 2155).
However, compared to 1H MRS, 31P MRS with a relatively low gyromagnetic ratio has a lower and limited sensitivity even at ultrahigh field.
Others have used 1D MRS to evaluate the PTSD.
13C MRS to determine cerebral glutamate turnover rate in partial ornithine transcarbamylase deficiency (OTCD).
We conclude with recommendations to improve study designs and 31P MRS methods in future studies.
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