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The collagenases (MMP-1, MMP-8, MMP-13), membrane-type 1 MMP and gelatinase (MMP-2) cleave fibrillar collagen into characteristic three-quarter and one-quarter length fragments and so are key enzymes involved in cartilage collagen turnover.
For an overview, data published so far are summarized in Additional file 1: MMP expression in gynecological cancer cell lines.
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Conclusion: (1) Collagenase 1 (MMP-1) is a physiologic constituent of amniotic fluid.
Results: (1) MMP-1 was detectable in 81.3% of amniotic fluid samples (287/353), and its concentrations increased with advancing gestational age (r = 0.4; P <.001).
This subfamily includes, among others, collagenase 1 (MMP-1), and collagenase 3 (MMP-13).
Matrix Metallopeptidase 1 (MMP-1) expression has repeatedly been correlated to tumorigenesis and metastasis.
Total matrix metalloproteinase 1 (MMP-1), MMP-3, tissue inhibitor of matrix metalloproteinase 1 (TIMP-1) or plasminogen activator inhibitor 1 (PAI-1) in cell culture medium was measured using enzyme-linked immunosorbent assay (ELISA) kits from R&D Systems.
In addition, Borghaei and colleagues [ 52] have shown that IL-4 suppresses the IL-1-induced transcription of collagenase 1 (MMP-1) and stromelysin-1 (MMP-3) in human synovial fibroblasts.
Thus, experimental studies showed that androgens, via AR-Ets, negatively regulate the expression of interstitial collagenase (MMP -1), stromelisin-1 (MMP -3), and matrilysin -1 (MMP -7) [ 45].
Treatment of Oryeongsan was increased on HG-reduced MT-1 MMP expression.
Eight hours after the addition of IGF-1, MMP activity was assayed in the conditioned media.
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