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Approximately 25% of pregnant women will experience at least 1 miscarriage (1, 2 ).
However, during 2012 and 2013, serotype 4b isolates of different genotypes also infected 5 pregnant women, resulting in 1 miscarriage, 3 premature newborns, and 1 stillborn infant and 1 premature newborn in a twin pregnancy.
During August 2012, a fifth outbreak-associated subtype responsible for 1 case was detected, and CDC reported a final total of 147 cases from 28 US states, causing 33 deaths and 1 miscarriage (www.cdc.gov/listeria/outbreaks/cantaloupes-jensen-farms/index.html).html
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High chorionic gonadotropin levels (MoM≥2.02) were associated with intrauterine growth restriction (odds ratio=2.1; P<0.05), miscarriage (odds ratio=4; preterm, preterm birth (odds ratio=2.5; P<0.05), and intrauterine fetal death (odds ratio=4.2; P<0.01).
Results: High alpha-fetoprotein levels (MoM≥2.0) were found to be significantly more frequent (P<0.05) in cases of fetal growth restriction (odds ratio=2.7), miscarriage (odds ratio=4.4) and intrauterine fetal death (odds ratio=5.8).
Included patients (i) had a uterine septum, (ii) were of reproductive age, (iii) had a history of ≥1 miscarriage or infertility; (iv) intended to have children in the future and (v) provided informed consent for the study.
(2) Miscarriage or TOP: 63 days before.
Women with elevated TPOAb could have increased rates of infertility [ 8], miscarriage [ 9- 11] and perinatal death [ 12].
Dutch Trial Register: NTR3110 Miscarriage is a frequent complication in first trimester pregnancy which occurs in 10-15% of pregnant women and results in between 18.000 and 27.000 miscarriages in The Netherlands each year [ 1].
Except in Rao's work in Madras (4 ), miscarriage and premature birth were not separated, so they are described together.
6 Miscarriage is the most common adverse event of early pregnancy, occurring in approximately 20% of pregnancies.
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