To evaluate the potential therapeutic effect of PTP1B invalidation, we used PTP1B-/ mice.
Furthermore, Fgfr2b invalidation (Fgfr2b-/ mutant), results in a severe anorectal malformation as demonstrated in both landscape and cross sectional views.
Remarkably ACACB invalidation in patients' myoblasts decreased LD number and size while LPIN1 invalidation in controls induced LD accumulation.
Having found that ActivinB - a TGFβ superfamily member encoded by the Inhbb gene - is upregulated in insulinoma tumours caused by Men1 invalidation, we hypothesize that Menin could directly participate in the epigenetic-repression of Inhbb gene expression.
Objectives: The purpose of the present study was to assess the potential therapeutic effect of total PTP1B invalidation on glucose metabolism and cardiovascular insulin resistance using experimental model of sepsis.
The purpose of the present study was to assess the potential therapeutic effect of total PTP1B invalidation on glucose metabolism and cardiovascular insulin resistance using experimental model of sepsis.
Recently, another laboratory observed similar results on DNA replication after hPaf1 invalidation.
Defect in spindle formation may lead to the G2/M transition delay observed after hPaf1 invalidation.
Nm23-M1 invalidation was carried out so that a reporter gene (LACZ) was introduced in place of the disrupted gene.
Previously, we showed that heterozygous Scn5a invalidation in mouse produces ventricular rearrangements and fibrosis with aging [10], [11].
We have characterized in depth the phenotype of nm23-1 deletinn in the mammary gland in mice carrying whole body nm23-M1 invalidation.
