Hours of mechanical ventilation median 624 (ICR 451 1110), days of ICU stay median 26.5 (ICR 12 51) and in-hospital stay median 31 days (ICR 13 82).
The 2.4 kb long ICR [27], [28], [29], [30] is methylated in the sperm, but is unmethylated in the egg.
One hundred sixty 4-week-old CD-1 (ICR) male mice (20 ± 2 g body weight) were purchased from the Animal Center of Soochow University (China).
In this study [60], CD-1 (ICR) female mice were exposed to TiO2 NPs with different dosages (2.5, 5, and 10 mg/kg body weight).
In this study [25], CD-1 (ICR) female mice were treated with anatase (155 nm) or rutile (80 nm) TiO2 NPs.
In another report of the same research group [53], the elevated levels of GSH-Px, GST, GSH, and SOD in rutile group were significantly higher than that in control and anatase groups at the time point of 10 days after CD-1 (ICR) female mice were treated with TiO2 NPs.
Nano-anatase TiO2and bulk TiO2powder was dispersed onto the surface of 0.5%, w/v HPMC, and then the suspending solutions containing nano-TiO2and bulk TiO2particles were treated by ultrasonic for 30 min and mechanically vibrated for 5 min. CD-1 (ICR) mice of 70 females (20 ± 2 g) were purchased from the Animal Center of Soochow University.
Zhang et al. [59] investigated how different sizes, morphology, and surface modification of TiO2 NPs in rutile form regulated their toxic effects on the brain after CD-1 (ICR) female mice were exposed by intranasal instillation every other day for 30 days.
However, in another study [53], after the CD-1 (ICR) female mice were exposed to TiO2 NPs (rutile 80 nm and anatase 155 nm) every other day for 30 days by intranasal instillation, the activities of GSH-Px, GST, SOD, and GSH level in the brain were not changed at 30 days.
Hu et al. [83] revealed that after CD-1 (ICR) female mice were exposed to TiO2 NPs (6.5 nm; 5, 10, 50 mg/kg BW) by intragastric administration every day for 60 days, the expressions of apoptosis-related genes were affected.
Nano-anatase powder was dispersed onto the surface of 0.5%, w/v HPMC, and then the suspending solutions containing the TiO2 colloidal suspensions were treated by ultrasonic for 30 min and mechanically vibrated for 5 min. CD-1 (ICR) mice of 60 females (20 ± 2 g) were purchased from the Animal Center of Soochow University.
