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In this analysis the individuals clustered mainly into two groups: 1) ICD and 2) healthy + CCD, similar to what we found with the PCA plot of the original metabolite data (Figure S1).
Prominent Notch activity is represented in this group by high levels of the active cleaved form of Notch 1 (Notch 1 ICD) as well as of ligands Jagged (JAG1) and Delta-like 1 (DLL1) and of the downstream Notch transcriptional target HES1.
Additional file 1: ICD CODES.
Additional file 1: ICD codes and pelvic inflammatory disease conditions.
Finally, Delta-like 1 ICD production was demonstrated to block proliferation, cell motility, and neuronal migration, independently of its activity as a Notch receptor ligand.
Between 1996 and 2000, the manufacturer reported 23 adverse events associated with this product, which was used during the extraction of 9 pacemaker leads, 1 ICD lead, and 13 unspecified leads.
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Legend: Sub-sample 1: ICD and non ICD patients with the same primary diagnosis (+ other controls); Sub-sample 2: ICD and non ICD patients with the same primary diagnosis and Charlson index (+ other controls; Case: Patients with ICD; Controls: Patients without ICD; Standardized difference = After-matching standardized differences between case and control groups; LOS = Length of Stay in day.
Four cases had no episode of a headache in 1 IC-Pcom, 2 large IC-Pcom and 1 IC-Acho.
They comprise the default mode network (IC(2), IC 9), IC(10)) and brain regions involved in visual (IC(1), IC(4)), auditory/motor (IC 5)), sensory/motor (IC 8)), attentional (IC 7), IC 6), IC(12), IC(13)) and executive functions (IC 7), IC(11), IC(14)).
Parallel cycle (PC) and indirect condensation 1 (IC 1) architecture (b).
This index ranges between 0 and 1, Ic = 1 indicates full cancellation and Ic = 0 indicates no cancellation effect.
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