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Figure 1 IAP at different time intervals.
The total number of measurements was 400. Figure 1 IAP measurement technique.
As stated by the consensus, IAH was considered when the measured IAP values exceeded 12 mmHg [1]. Figure 1 IAP measurement technique.
On the other hand, ICU survivors had significantly lower day 1 IAP (13 ± 4 mmHg vs. 16 ± 5 mmHg, p = 0.015) and higher APP (59 ± 7 mmHg vs. 54 ± 8 mmHg, p = 0.02) compared to nonsurvivors.
Taking the work done on Drosophila as a reference, in our opinion two molecular factors deserve particular attention: (1) IAP: in Drosophila, dBruce has been shown to provide a mechanistic link between autophagy and cell death [ 48].
To evaluate the efficacy of surgical decompression, the following data were compared: 1) IAP, indirectly evaluated by measuring urinary bladder pressure; 2) Sequential Organ Failure Assessment Score (SOFA); 3) arterial plasma lactates (mmol/L).
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To determine the effect on anti-apoptosis gene expression, we measured the expression of the B-cell lymphoma 2 (BCL-2) and inhibitor of apoptosis 1 (IAP-1) genes.
† : before blood withdrawal, n = 9 at IAP 0, 30, 30 before FL, and 30 after FL; after blood withdrawal, n = 9 at IAP 0 and 30, n = 7 at IAP 30 before FL and 30 after FL.
Fig. 2 IAP distribution dependent on definition.
We also extracted data on MAP, CVP, ScvO2, IAP and APP.
There were 20 patients enrolled in the study with a total of 240 IAP measurements.
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Justyna Jupowicz-Kozak
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