The oxidative stress-responsive genes Gclm (~1.6-fold), Gsr (~2.5-fold), Hmox2 (~1.6-fold) and Nqo1 (~2.6-fold) exhibited induction.
Five out of eight Gpx genes identified in mammals (Gpx1, -3, -4, -7, and −8) and Gsr were detected in choroid plexuses.
In conclusion, we reported here that the gene expression of G6pd, 6pgd, Gsr, Gpx, and Gst did not correlate to enzyme activity, and the actual effect of long-term iron overload on renal antioxidant system is observed at protein level.
METHODS: For this prospective, nonrandomized study, 229 patients (37 GSR, 22 TAL, and 170 TAR alone) were examined.
The 263,425 successful GSRs were clustered and assembled [ 38] into 52,149 GSR assemblies (contigs) and 70,679 singletons (Table 2).
Two of these spots contained HSP (HSPA8, HSPB1, GSTP1, GSR, PDIA3, and PDIA3).
The GSR was created using AUTOGRAPH [ 116] to generate a database of predicted ORFs against the E. coli K-12 GSR, iAF1260 [ 115].
A total of 41,260 GSR assemblies and singletons were annotated, of which 19,786 have unique GenBank accession numbers.
In the PBHC sub-network, some genes such as CREG1, NTRK1, DUSP13, GSR, and TXNRD1 play a role in cell cycle and/or cell death.
